Publications by authors named "Valerie Perea"

The integrated stress response (ISR) comprises the eIF2α kinases PERK, GCN2, HRI, and PKR, which induce translational and transcriptional signaling in response to diverse insults. Deficiencies in PERK signaling lead to mitochondrial dysfunction and contribute to the pathogenesis of numerous diseases. We define the potential for pharmacologic activation of compensatory eIF2α kinases to rescue ISR signaling and promote mitochondrial adaptation in PERK-deficient cells.

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Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are linked in the onset and pathogenesis of numerous diseases. This has led to considerable interest in defining the mechanisms responsible for regulating mitochondria during ER stress. The PERK signaling arm of the unfolded protein response (UPR) has emerged as a prominent ER stress-responsive signaling pathway that regulates diverse aspects of mitochondrial biology.

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The integrated stress response (ISR) comprises the eIF2α kinases PERK, GCN2, HRI, and PKR, which induce translational and transcriptional signaling in response to diverse insults. Deficiencies in PERK signaling lead to mitochondrial dysfunction and contribute to the pathogenesis of numerous diseases. We define the potential for pharmacologic activation of compensatory eIF2α kinases to rescue ISR signaling and promote mitochondrial adaptation in PERK-deficient cells.

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Article Synopsis
  • CRY2 is a crucial component in the process of ubiquitination mediated by SCF for the protein c-MYC, and this role was previously not recognized.
  • The researchers conducted a mass spectrometry screen to find additional proteins that require CRY1 or CRY2 for their interaction with SCF, leading to the discovery of over a hundred potential substrates.
  • Among these, TLK2 was identified as a key substrate that relies on CRY1 and CRY2 for its interaction with SCF, suggesting a link between circadian rhythms and the cell cycle through CRY-influenced protein turnover.
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