Publications by authors named "Valerie Marcou"
Article Synopsis
- Early initiation of antiretroviral therapy (ART) in HIV-1-infected infants shows a positive impact on immune system health, specifically CD4 and CD8 T lymphocytes, but the effects in older children and adolescents need more study.
- The ANRS-EP59-CLEAC study examined 27 children and 9 adolescents who started ART early compared to 19 children and 21 adolescents who started later, revealing that early treatment leads to higher CD8 T cell percentages.
- Overall, while early ART benefits CD8 T cells significantly, the impact on CD4 T cells is less pronounced, suggesting late-treated pediatric patients can still effectively counteract CD4 T-cell loss through thymus production.
Eleven newborns from 25 to 32 weeks of gestational age, weighting from 0.66 to 1.60 kg received 2 mg/kg doses of nevirapine syrup.
View Article and Find Full Text PDFTo identify factors associated with vaginal colonization and persistence by group B Streptococcus (GBS) and by the hypervirulent neonatal CC-17 clone in late pregnancy and after delivery, a multicentre prospective observational cohort with 3-month follow-up was established in two university hospitals, Paris area, France. Pregnant women were recruited when antenatal screening for GBS vaginal colonization at 34-38 weeks of gestational age was positive. Vaginal samples were analysed by conventional culture methods at antenatal screening, delivery, and 21 and 60 days following delivery.
View Article and Find Full Text PDFBackground: In infants, the mode of acquisition of CC17 group B Streptococcus (GBS), the hypervirulent clone responsible for late-onset disease (LOD), remains elusive.
Methods: In a prospective multicenter study in France, we evaluated GBS colonization in mother-baby pairs with 2 months of follow-up between 2012 and 2015. Criteria included positivity for GBS colonization at antenatal screening or at delivery.