Publications by authors named "Valerie Laferl"
Liver resection (LR) is the primary treatment for hepatic tumors, yet posthepatectomy liver failure (PHLF) remains a significant concern. While the precise etiology of PHLF remains elusive, dysregulated inflammatory processes are pivotal. Therefore, we explored the theragnostic potential of extracellular high-mobility-group-box protein 1 (HMGB1), a key damage-associated molecular pattern (DAMP) released by hepatocytes, in liver recovery post LR in patients and animal models.
View Article and Find Full Text PDFArticle Synopsis
- Posthepatectomy liver failure (PHLF) is a major cause of short-term death after liver surgery, and this study evaluates the effectiveness of two liver function tests: APRI+ALBI and LiMAx.
- The study analyzed 352 patients from four European centers, comparing the predictive potential of both tests for significant PHLF and 90-day mortality using statistical methods.
- Results showed that APRI+ALBI was more effective than LiMAx in predicting PHLF grades B and C as well as 90-day mortality, and it was also less costly and less labor-intensive.