Overall survival of patients with KIT-mutant metastatic GIST in the era of multiple kinase inhibitor availability.

Purpose: The prognosis of patients with metastatic GIST and imatinib-sensitive primary mutations has significantly improved. However, limited data are available to inform patients about outcomes across different lines of treatment. This retrospective analysis aims to evaluate patient outcomes at a large German GIST referral center over the past 15 years.

Sleep reduces the testing effect-But not after corrective feedback and prolonged retention interval.

Retrieval practice relative to restudy of learned material typically attenuates time-dependent forgetting. A recent study examining this testing effect across 12-h delays filled with nocturnal sleep versus daytime wakefulness, however, showed that sleep directly following encoding benefited recall of restudied but not of retrieval practiced items, which reduced, and even eliminated, the testing effect after sleep (Bäuml, Holterman, & Abel, 2014). The present study investigated, in 4 experiments, whether this modulating role of sleep for the testing effect is influenced by two factors that have previously been shown to increase the testing effect: corrective feedback and prolonged retention intervals.