Publications by authors named "Valerie Bourque-Riel"
Article Synopsis
- The study examines the effect of resolvin D1 (RvD1), derived from omega-3 fatty acids, on heart infarct size and its interaction with linoleic acid (LA), an omega-6 fatty acid.
- Increased levels of LA were found to diminish the cardioprotective benefits of RvD1, leading to larger infarct sizes in rats.
- The findings suggest that reducing omega-6 PUFA intake may be important to preserve the heart-protective effects of omega-3 PUFAs like RvD1.
Although controversial, some data suggest that omega-3 polyunsaturated fatty acids (PUFA) are beneficial to cardiovascular diseases, and could reduce infarct size. In parallel, we have reported that the administration of Resolvin D1 (RvD1), a metabolite of docosahexaenoic acid, an omega-3 PUFA, can reduce infarct size. The present study was designed to determine if the inhibition of two important enzymes involved in the formation of RvD1 from omega-3 PUFA could reduce the cardioprotective effect of omega-3 PUFA.
View Article and Find Full Text PDFThis study was designed to determine if Resolvin D1 (RvD1), a pro-resolution metabolite of the omega-3 polyunsaturated fatty acid docosahexaenoic acid, could decrease myocardial infarct size with delivered at the onset of ischemia. Male Sprague Dawley rats underwent 40 minutes of myocardial ischemia followed by reperfusion. These animals received 1 intraventricular injection of RvD1 (0.
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