Publications by authors named "Valerie Bourguignon"

Article Synopsis
  • The study investigates how dihydrouridine modifications in tRNA affect gene expression during stress, particularly in response to oxidative conditions in Escherichia coli.
  • Researchers manipulated the redox state using paraquat and found that different tRNA-dihydrouridine synthases (DusA, DusB, DusC) have varying sensitivities to oxidative stress, influencing dihydrouridine levels.
  • The findings highlight the role of NADPH availability in tRNA modification and provide new insights into how cells respond to oxidative stress through redox dynamics.
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Purpose: Medulloblastoma (MB) is the most prevalent paediatric brain tumour. Despite improvements in patient survival with current treatment strategies, the quality of life of these patients remains poor owing to the sequelae and relapse risk. An alternative, or, in addition to the current standard treatment, could be considered immunotherapy, such as Natural Killer cells (NK).

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During their maturation, ribosomal RNAs (rRNAs) are decorated by hundreds of chemical modifications that participate in proper folding of rRNA secondary structures and therefore in ribosomal function. Along with pseudouridine, methylation of the 2'-hydroxyl ribose moiety (Nm) is the most abundant modification of rRNAs. The majority of Nm modifications in eukaryotes are placed by Fibrillarin, a conserved methyltransferase belonging to a ribonucleoprotein complex guided by C/D box small nucleolar RNAs (C/D box snoRNAs).

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Modification of tRNA is an integral part of the epitranscriptome with a particularly pronounced potential to generate diversity in RNA expression. Eukaryotic tRNA contains modifications in up to 20% of their nucleotides, but not all sites are always fully modified. Combinations and permutations of partially modified sites in tRNAs can generate a plethora of tRNA isoforms, termed modivariants.

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