The Role of Polygenic Score and Cognitive Activity in Cognitive Functioning Among Older Adults.

Background And Objectives: This study explored whether the intensity of cognitive activities could moderate the relationship between a genetic predisposition for developing Alzheimer's disease (AD) and cognitive functioning among older adults in the United States. Furthermore, we examined whether the same moderating effects were dependent on different measures of cognition.

Research Design And Methods: We used a data set from the 2000-2014 waves of the Health and Retirement Study and the Consumption and Activities Mail Survey.