Guideline adaptation and implementation planning: a prospective observational study.

Background: Adaptation of high-quality practice guidelines for local use has been advanced as an efficient means to improve acceptability and applicability of evidence-informed care. In a pan-Canadian study, we examined how cancer care groups adapted pre-existing guidelines to their unique context and began implementation planning.

Methods: Using a mixed-methods, case-study design, five cases were purposefully sampled from self-identified groups and followed as they used a structured method and resources for guideline adaptation.

Mortality among contraceptive pill users: cohort evidence from Royal College of General Practitioners' Oral Contraception Study.

Objective: To see if the mortality risk among women who have used oral contraceptives differs from that of never users.

Design: Prospective cohort study started in 1968 with mortality data supplied by participating general practitioners, National Health Service central registries, or both.

Setting: 1400 general practices throughout the United Kingdom.

Cancer risk among users of oral contraceptives: cohort data from the Royal College of General Practitioner's oral contraception study.

Objective: To examine the absolute risks or benefits on cancer associated with oral contraception, using incident data.

Design: Inception cohort study.

Setting: Royal College of General Practitioners' oral contraception study.