Association between Itch and Cancer in 3836 Pediatric Pruritus Patients at a Tertiary Care Center.

: Pruritus is a well-recognized paraneoplastic phenomenon. Previous studies have examined the association of itch with a variety of malignancies in adults. However, no large study has examined this association in a pediatric population.

Association between itch and cancer in 16,925 patients with pruritus: Experience at a tertiary care center.

Background: Pruritus has been associated with cancer. However, limited data are available on the types of underlying malignancies associated with pruritus.

Objective: We sought to characterize the association between pruritus and different cancer types, as well as variations by racial group.

Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility.

The inwardly rectifying K channel K4.1 is broadly expressed by CNS glia and deficits in K4.1 lead to seizures and myelin vacuolization.

Novel mutation in the KCNJ10 gene in three siblings with seizures, ataxia and no electrolyte abnormalities.

We report a consanguineous family with three affected siblings with novel mutation in the KCNJ10 gene. All three presented with central nervous system symptoms in the form of infantile focal seizures, ataxia, slurred speech with early developmental delay and intellectual disability in two siblings. None had any associated electrolyte abnormalities and no symptomatic hearing deficits were observed.

Electrophysiological properties of NG2(+) cells: Matching physiological studies with gene expression profiles.

NG2(+) glial cells are a dynamic population of non-neuronal cells that give rise to myelinating oligodendrocytes in the central nervous system. These cells express numerous ion channels and neurotransmitter receptors, which endow them with a complex electrophysiological profile that is unique among glial cells. Despite extensive analysis of the electrophysiological properties of these cells, relatively little was known about the molecular identity of the channels and receptors that they express.