Novel Hematological Biomarker Adopted for Early Sepsis Detection Emerges as Predictor of Severity for COVID Infection.

Sepsis is a major health care burden with significant contribution to morbidity, mortality, and hospital resource utilization. Monocyte Distribution Width (MDW), the novel hematological biomarker, was clinically implemented in our laboratory for early detection of sepsis (ESId) in 2019. When COVID-19 pandemic hit in 2020, we noticed some similarities of the laboratory data of the COVID patients with patients previously diagnosed with sepsis.

A Case Report of Acquired Factor X Deficiency in a Patient With Multiple Myeloma.

Multiple myeloma is a plasma cell neoplasm characterized by clonal proliferation of immunoglobulin producing terminally differentiated B cells. Classically patients are described to present with bone pain, hypercalcemia, anemia, and/or renal impairment. A less described clinical manifestation related to the myeloma is acquired coagulation abnormalities including paraprotein interfering with the coagulation cascade or exhibiting specific antibody activity.

Tumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid Cancer.

Context: Five to 10% of patients with differentiated thyroid cancers (DTC) develop invasive and/or distant metastatic disease that is marginally improved with standard therapies. Prognosis is poor for patients with anaplastic thyroid cancer, with a median survival of 3-5 months. We suggest that a paradigm shift is necessary in the treatment of advanced cases.

PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer.

Regional metastatic differentiated thyroid cancer (mDTC) provides a unique model in which to study the tumor-immune interface. These lymph node metastases persist for years, generally without progression to distant metastases. Although the immune system likely impedes disease progression, it is unsuccessful in eliminating disease.