Publications by authors named "Valeria Sperandio Roxo"
Article Synopsis
- Cervical cancer (CC) is a significant global health issue, with over 500,000 new cases annually, primarily caused by human papillomavirus (HPV) which can evade the immune system, leading to persistent infections and cervical neoplasia.
- The immune system's response to viral infections is crucial in the development of CC, particularly through the interaction between HLA-E ligands on target cells and CD94/NKG2 receptors on natural killer (NK) cells, influencing their cytotoxic activity.
- Increased HLA-E expression is linked to high-risk HPV types (16 and 18) and is associated with better survival rates in cervical cancer patients, highlighting its immunological significance in HPV
Human papillomavirus (HPV) can induce cervical intraepithelial neoplasias (CIN) grades 1, 2 and 3. Untreated, these lesions may progress to cervical cancer (CC) which is the third most common cancer in women worldwide. HLA-G plays an immunotolerant role in the immune response.
View Article and Find Full Text PDFObjective: The aim of the present study was to investigate a broad spectrum of autoantibodies in patients with endemic pemphigus foliaceus (EPF)-fogo selvagem-and to determine the possible association between EPF and other autoimmune diseases.
Materials And Methods: Indirect immunofluorescence was used to test 120 patients with EPF and 200 healthy controls for the presence of the following autoantibodies: anti-desmoglein-1 (APF), anti-neutrophil cytoplasmic (ANCA), anti-smooth muscle (SMA), anti-mitochondrial (AMA), anti-nuclear (ANA), anti-liver kidney microsomal (LKM), anti-gastric parietal cells (GPCA) and anti-thyroid microsome (TMA).
Results: APF antibodies were detected in 62.