Normalization as a mediator of emotion during unemployment.

Meta-analyses indicated detrimental effects on some psychological dimensions from job loss and extended periods of unemployment. This study analyses three phenomena: causes attributed to unemployment; processes for coping with unemployment; and the emotional impact of joblessness. Using an SEM approach, a model is created in which unemployment normalization acts as a mediator between locus of control and emotions.

Correction: miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

miR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer.

Background: Metabolic reprogramming towards aerobic glycolysis in cancer supports unrestricted cell proliferation, survival and chemoresistance. The molecular bases of these processes are still undefined. Recent reports suggest crucial roles for microRNAs.

Friend or foe? The tumour microenvironment dilemma in colorectal cancer.

The network of bidirectional homotypic and heterotypic interactions established among parenchymal tumour cells and surrounding mesenchymal stromal cells generates the tumour microenvironment (TME). These intricate crosstalks elicit both beneficial and adverse effects on tumour initiation and progression unbalancing the signals and responses from the neighbouring cells. Here, we highlight the structure, activities and evolution of TME cells considering a novel colorectal cancer (CRC) classification based on differential stromal composition and gene expression profiles.

Deregulated expression of cryptochrome genes in human colorectal cancer.

Background: Circadian disruption and deranged molecular clockworks are involved in carcinogenesis. The cryptochrome genes (CRY1 and CRY2) encode circadian proteins important for the functioning of biological oscillators. Their expression in human colorectal cancer (CRC) and in colon cancer cell lines has not been evaluated so far.