Publications by authors named "Valeria Putzolu"
Standard interferon treatment is known to increase the risk of infections; this risk also needs to be evaluated in clinical practice for pegylated interferon. To this end, we studied 255 patients treated with standard (103) or pegylated (152) interferon, in combination with ribavirin, for hepatitis C. Overall, 31 anti-hepatitis C virus treatment-related infections were observed.
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- The study aimed to analyze the incidence and risk factors of severe hepatotoxicity (SH) during antiretroviral treatment (ART) among HIV-positive patients, finding a 4.2% incidence rate with most cases linked to chronic viral hepatitis.
- It observed that SH was primarily associated with increased liver enzymes and a significant correlation was noted between liver enzyme levels and improvements in CD4 T-cell counts.
- The research concluded that patients with low CD4 counts (<200 cells/mm³) require close monitoring for liver damage, suggesting that preventive treatments for hepatitis could help mitigate risks during ART.