Publications by authors named "Valeria Mezzano-Robinson"
Article Synopsis
- Oral cancer causes significant pain linked to the activation of protease-activated receptor 2 (PAR) in cancer cells and neurons, contributing to nociception (pain sensation).
- Researchers found that inhibiting PAR using nanoparticles to deliver the drug AZ3451 is more effective in reversing pain compared to the drug alone, especially in mouse models of oral cancer pain.
- The study also shows that both the overexpression of the F2RL1 gene in cancer cells and neurons plays a role in pain, and targeting PAR could improve pain management and oral function for patients.
Digital spatial profiling to predict recurrence in grade 3 stage I lung adenocarcinoma.
J Thorac Cardiovasc Surg
September 2024
Objective: Early-stage lung adenocarcinoma is treated with local therapy alone, although patients with grade 3 stage I lung adenocarcinoma have a 50% 5-year recurrence rate. Our objective is to determine if analysis of the tumor microenvironment can create a predictive model for recurrence.
Methods: Thirty-four patients with grade 3 stage I lung adenocarcinoma underwent surgical resection.