Publications by authors named "Valeria Guarnaccia"
Article Synopsis
- Retinoids show potential in treating breast cancer, particularly in estrogen receptor-positive cells (like MCF-7), by suppressing cell growth through all-trans-retinoic acid (ATRA).
- ATRA induces the expression of the pro-oncogenic microRNA miR-21 in ERα(+) cells, which can counteract ATRA's anti-proliferative effects but also decrease cell motility.
- miR-21's regulation involves RARα binding to its gene, and targeting it could enhance ATRA's effectiveness against cancer growth while affecting related proteins like maspin and gene targets such as IL1B, ICAM-1, and PLAT.
The peptidyl-prolyl-isomerase Pin1 interacts with phosphorylated proteins, altering their conformation. The retinoic acid receptor RARalpha and the acute-promyelocytic-leukemia-specific counterpart PML-RARalpha directly interact with Pin1. Overexpression of Pin1 inhibits ligand-dependent activation of RARalpha and PML-RARalpha.
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