Publications by authors named "Valeria C Santa Rita Pereira"
Genetic association study of the HLA class II alleles DRB1, DQA1, and DQB1 in patients with pharmacoresistant temporal lobe epilepsy associated with mesial hippocampal sclerosis.
Wagner G Horta Eduardo Paradela André Figueiredo Isabella D'Andrea Meira Valéria C Santa Rita Pereira
Seizure
September 2015
Article Synopsis
- Temporal lobe epilepsy (TLE) is common in adults and its connection with neuroinflammation, particularly in cases like TLE with mesial hippocampal sclerosis (TLE-HS), is being explored for genetic susceptibility.
- The study involved analyzing blood samples from 42 individuals with drug-resistant TLE-HS and 89 healthy controls to investigate the association of TLE-HS with specific HLA class II alleles using advanced genetic testing methods.
- While the HLA-DRB1*13:02 allele showed a statistically significant difference in frequency between the patient and control groups, this significance diminished after adjusting for multiple comparisons, indicating it may have a weak association with TLE-HS susceptibility.