Aqueous humor renin, angiotensin I, and angiotensin II activity in primary open-angle glaucoma.

Purpose: The renin-angiotensin system is involved in the pathogenesis of retinal ischemic conditions and glaucoma. Our objective was to evaluate the renin, angiotensinconverting enzyme 1, and angiotensin-converting enzyme 2 activities in aqueous humor and blood samples of patients with and without primary open-angle glaucoma.

Methods: We analyzed samples from 56 participants who underwent ocular surgeries.