Publications by authors named "Valeria Barcelli"
Article Synopsis
- Tuberculosis (TB) is caused by the airborne bacteria Mycobacterium tuberculosis (Mtb), and while the role of antibodies in protecting against it isn't fully understood, they may play a crucial part in host defense.
- This study analyzed the IgG/IgA memory B cell responses in healthy individuals exposed to TB, identifying a human monoclonal antibody that can protect against the disease by targeting a specific virulence factor called LpqH.
- Findings showed that the protective effects varied depending on the antibody type, with IgG2 and IgA providing the strongest defense, suggesting new avenues for improving TB vaccines and understanding natural immunity.
