Publications by authors named "Valeria Astorino"
Article Synopsis
- Respiratory Syncytial Virus (RSV) is a leading cause of respiratory infections in young children, and the study aimed to explore how the SARS-CoV-2 pandemic affected RSV hospitalizations in kids.
- An analysis of children hospitalized for RSV from 2014 to 2023 revealed a significant increase in hospitalizations after the pandemic, particularly among older children, with 70% under one year old and many needing ICU care.
- Preventive strategies like Nirsevimab could have reduced hospitalizations by over 46%, and including older children with comorbidities could increase this prevention rate to more than 57%.
Expanded Newborn Screening for Inborn Errors of Immunity: The Experience of Tuscany.
J Allergy Clin Immunol Pract
June 2024
Article Synopsis
- Inborn errors of immunity (IEIs) are inherited disorders that significantly increase the risk of severe infections and other serious health issues, with early detection being crucial, especially for severe combined immunodeficiency in newborns.
- A study in Tuscany, Italy, assessed the effectiveness of an expanded newborn screening (NBS) strategy that used advanced assays to identify various IEIs in infants born between 2018 and 2022.
- The findings showed a referral rate consistent with existing literature and a diagnosis rate of 1 in 9431 newborns, marking a successful implementation of a real-life NBS program aimed at improving early intervention for affected infants.
Aim: To estimate hospitalisation rate and investigate the role of age, prematurity and vaccination status in severe pertussis cases.
Methods: We retrospectively evaluated 200 children aged 0-14 years, admitted to the emergency rooms of Meyer Hospital of Florence and Pisa Hospital with a diagnosis of pertussis from 1 October 2010 to 31 January 2020.
Results: Children younger than 12 months were 63.
This cross-sectional study, including children hospitalized for severe acute respiratory syndrome coronavirus 2 infection, demonstrates for the first time that nonhealthcare worker parents perform similarly to healthcare workers in the administration to their children of an unsupervised nasal swab for severe acute respiratory syndrome coronavirus 2 detection by following written instructions and video tutorials.
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