Mechanisms of Antioxidant Protection of Low-Density Lipoprotein Particles Against Free Radical Oxidation.

It was found out that when the patients with atherosclerosis are orally administered ubiquinone Q (CoQ), oxidation (lipid hydroperoxide content) of the low-density lipoprotein (LDL) particles sharply decreases, which confirms important role of this natural antioxidant in protecting LDL particles from free radical oxidation . Influence of the lipophilic natural antioxidants ubiquinol Q (CoQH) and α-tocopherol (α-TOH) on the kinetic parameters of Cu-induced free radical oxidation of LDL particles was investigated. In this model system, possible synergism of the antioxidant action of CoQH and α-TOH has been shown.