Publications by authors named "Valenzuela S"

Background: Personal Protective Equipment (PPE) is crucial for minimizing workplace hazards, and its effectiveness relies on adapting to diverse anthropometric features.

Objective: To establish the first 3D anthropometry database of Chilean workers.Also, this study compares 18 dimensions with the North American CAESAR three-dimensional anthropometrical scan database.

View Article and Find Full Text PDF

van der Waals heterostructures provide a versatile platform for tailoring electrical, magnetic, optical and spin transport properties via proximity effects. Hexagonal transition metal dichalcogenides induce valley Zeeman spin-orbit coupling in graphene, creating spin lifetime anisotropy between in-plane and out-of-plane spin orientations. However, in-plane spin lifetimes remain isotropic due to the inherent heterostructure's three-fold symmetry.

View Article and Find Full Text PDF

Mitochondria produces energy through oxidative phosphorylation (OXPHOS), maintaining calcium homeostasis, survival/death cell signaling mechanisms, and redox balance. These mitochondrial functions are especially critical for neurons. The hippocampus is crucial for memory formation in the brain, which is a process with high mitochondrial function demand.

View Article and Find Full Text PDF

Introduction: As climate change advances, the looming threat of dengue fever, intricately tied to rising temperatures, intensifies, posing a substantial and enduring public health challenge in the Philippines. This study aims to investigate the historical and projected excess dengue disease burden attributable to temperature to help inform climate change policies, and guide resource allocation for strategic climate change and dengue disease interventions.

Methods: The study utilized established temperature-dengue risk functions to estimate the historical dengue burden attributable to increased temperatures.

View Article and Find Full Text PDF

The COVID-19 pandemic has prompted the need for the development of new biosensors for SARS-CoV-2 detection. Particularly, systems with qualities such as sensitivity, fast detection, appropriate to large-scale analysis, and applicable in situ, avoiding using specific materials or personnel to undergo the test, are highly desirable. In this regard, developing an electrochemical biosensor based on peptides derived from the angiotensin-converting enzyme receptor 2 (ACE2) is a possible answer.

View Article and Find Full Text PDF

Importance: Diabetes is associated with emotional distress and poor mental health, especially for individuals with low income, hindering patients' ability to manage their condition. The health care system's workforce constraints limit its capacity to holistically support patients.

Objective: To assess the effectiveness of layperson-delivered empathetic engagement over the telephone in helping improve glycemic management for patients with diabetes.

View Article and Find Full Text PDF

Background: Cryoprecipitate-poor plasma (CPP) has been suggested as a promising alternative to the standard fresh frozen plasma (FFP) in plasma exchange therapy (TPE) for thrombotic thrombocytopenic purpura (TTP) given its lower concentrations of von Willebrand Factor (VWF). However, its efficacy and safety remain a topic of debate.

Study Design And Methods: We conducted a systematic review and meta-analysis comparing CPP to FFP during TPE in patients with TTP.

View Article and Find Full Text PDF
Article Synopsis
  • * There are two main types of craniopharyngioma: adamantinomatous, which is common in children and linked to mutations in the CTNNB1 gene, and papillary, which mainly affects adults and is associated with BRAF mutations.
  • * Treatment requires specialized centers to balance effective tumor removal with the preservation of critical brain function, and while surgery is essential, radiotherapy is used to minimize recurrence, alongside emerging targeted medical therapies.
View Article and Find Full Text PDF
Article Synopsis
  • - Ruxolitinib, a JAK1/JAK2 inhibitor, shows improved effectiveness in managing polycythemia vera (PV) compared to best available therapy (BAT), with higher rates of hematocrit control and treatment response, especially in patients resistant to hydroxyurea.
  • - The analysis of six studies with over 1,000 patients found that ruxolitinib also significantly improved symptoms related to myeloproliferative neoplasms.
  • - While ruxolitinib reduces thromboembolism risk, it is linked to increased rates of anemia, herpes zoster infections, and nonmelanoma skin cancer.
View Article and Find Full Text PDF
Article Synopsis
  • Multimorbidity, the presence of two or more chronic diseases, is a significant public health issue, especially among adults in socially deprived areas who face higher disease burdens and limited resources.
  • A study analyzed electronic health record data from over 816,000 patients using mixed-effects Poisson regression to explore the link between social deprivation and chronic disease accumulation across the U.S.
  • Results showed that people in more deprived areas had higher initial chronic disease counts, although they tended to accumulate additional diseases more slowly, highlighting the need to consider social factors in public health strategies.
View Article and Find Full Text PDF

The Philippines faces a complex and interconnected web of human, animal, and environmental health issues, including zoonotic and reverse zoonotic diseases, antimicrobial resistance, food insecurity and contamination, and threats from environmental degradation. This paper examines these issues, existing interventions, and their implementation challenges. The overall framework used to analyze the level of operationalization of the One Health approach is the Multi-sectoral One Health Coordination Framework developed by the World Health Organization, Food and Agriculture Organization, and the World Organization for Animal Health.

View Article and Find Full Text PDF

Background And Objectives: Factors associated with physician practice choice include residency location, training experiences, and financial incentives. How length of training affects practice setting and clinical care features postgraduation is unknown.

Methods: In this Length of Training Pilot (LoTP) study, we surveyed 366 graduates of 3-year (3YR) and 434 graduates of 4-year (4YR) programs 1 year after completion of training between 2013 and 2021.

View Article and Find Full Text PDF
Article Synopsis
  • A study was conducted on pediatric patients with sellar-suprasellar tumors to create a deep learning algorithm for better classification using MRI images.
  • 226 Chilean patients were analyzed, categorized into three groups: healthy controls, craniopharyngioma, and other sellar/suprasellar tumors.
  • The findings showed a high predictive positive value (PPV) and negative predictive value (NPV) for the algorithm, highlighting the potential of explainable AI in assisting radiological diagnoses.
View Article and Find Full Text PDF

Previous research has demonstrated that the human papillomavirus (HPV) can infect a wide range of human tissues, including those within the oral cavity. High-risk oral HPV strains have been associated with the development and progression of oral cancers, including oral squamous cell carcinomas. Although many studies have examined the prevalence of the high-risk strains HPV16 and HPV18, far fewer have assessed the prevalence of other high-risk HPV strains.

View Article and Find Full Text PDF

The rise of bots that mimic human behavior represents one of the most pressing threats to healthy information environments on social media. Many bots are designed to increase the visibility of low-quality content, spread misinformation, and artificially boost the reach of brands and politicians. These bots can also disrupt civic action coordination, such as by flooding a hashtag with spam and undermining political mobilization.

View Article and Find Full Text PDF

Background: Antibiotic therapy for patients with early Lyme disease is necessary to prevent later-stage Lyme disease complications. This systematic review and meta-analysis compares shorter versus longer antibiotic regimens in treating early Lyme disease.

Methods: A systematic search of PubMed, Embase, and Cochrane Central Register of Controlled Trials was conducted up to November 2023.

View Article and Find Full Text PDF

Topological insulators (TIs) hold promise for manipulating the magnetization of a ferromagnet (FM) through the spin-orbit torque (SOT) mechanism. However, integrating TIs with conventional FMs often leads to significant device-to-device variations and a broad distribution of SOT magnitudes. In this work, we present a scalable approach to grow a full van der Waals FM/TI heterostructure by molecular beam epitaxy, combining the charge-compensated TI (Bi,Sb)Te with 2D FM FeGeTe (FGT).

View Article and Find Full Text PDF

The bark is the outermost defense of trees against microbial attack, largely thanks to toxicity and prevalence of extractive compounds. Nevertheless, bark decomposes in nature, though by which species and mechanisms remains unknown. Here, we have followed the development of microbial enrichments growing on spruce bark over six months, by monitoring both chemical changes in the material and performing community and metagenomic analyses.

View Article and Find Full Text PDF

Nanocrystal gels exhibit collective optical phenomena based on interactions among their constituent building blocks. However, their inherently disordered structures have made it challenging to understand, predict, or design properties such as optical absorption spectra that are sensitive to the coupling between the plasmon resonances of the individual nanocrystals. Here, we bring indium tin oxide nanocrystal gels under chemical control and show that their infrared absorption can be predicted and systematically tuned by selecting the nanocrystal sizes and compositions and molecular structures of the link-mediating surface ligands.

View Article and Find Full Text PDF

Neuronanomedicine is an emerging multidisciplinary field that aims to create innovative nanotechnologies to treat major neurodegenerative disorders, such as Alzheimer's (AD) and Parkinson's disease (PD). A key component of neuronanomedicine are nanoparticles, which can improve drug properties and demonstrate enhanced safety and delivery across the blood-brain barrier, a major improvement on existing therapeutic approaches. In this review, we critically analyze the latest nanoparticle-based strategies to modify underlying disease pathology to slow or halt AD/PD progression.

View Article and Find Full Text PDF
Article Synopsis
  • HPV infections cause significant medical costs and new cancer cases annually, but vaccination rates in rural areas are low due to parental attitudes.
  • A survey was created to investigate how parents discuss HPV vaccination with healthcare providers during visits, focusing on their knowledge and confidence regarding the vaccine.
  • Results showed that many parents were already informed about HPV and considered vaccination for their children, but the intervention designed to improve vaccination rates did not show a significant impact.
View Article and Find Full Text PDF

Background: Temperature has a significant impact on dengue incidence, however, changes on the temperature-dengue relationship across axes of socio-economic vulnerability is not well described. This study sought to determine the association between dengue and temperature in multiple locations in the Philippines and explore the effect modification by socio-economic factors.

Method: Nationwide dengue cases per province from 2010 to 2019 and data on temperature were obtained from the Philippines' Department of Health-Epidemiological Bureau and ERA5-land, respectively.

View Article and Find Full Text PDF

Carbon dots (CDs) have been quickly extended for nanomedicine uses because of their multiple applications, such as bioimaging, sensors, and drug delivery. However, the interest in increasing their photoluminescence properties is not always accompanied by cytocompatibility. Thus, a knowledge gap exists regarding their interactions with biological systems linked to the selected formulations and synthesis methods.

View Article and Find Full Text PDF

Cannabidiol (CBD), derived from the cannabis plant, has gained significant attention due to its potential therapeutic benefits. However, one of the challenges associated with CBD administration is its low bioavailability, which refers to the fraction of an administered dose that reaches systemic circulation. This limitation necessitates the exploration of various approaches to enhance the bioavailability of CBD, thus helping to maximize its therapeutic potential.

View Article and Find Full Text PDF

Chloride intracellular ion channel (CLIC) proteins exist as both soluble and integral membrane proteins, with CLIC1 capable of shifting between two distinct structural conformations. New evidence has emerged indicating that members of the CLIC family act as moonlighting proteins, referring to the ability of a single protein to carry out multiple functions. In addition to their ion channel activity, CLIC family members possess oxidoreductase enzymatic activity and share significant structural and sequence homology, along with varying overlaps in their tissue distribution and cellular localization.

View Article and Find Full Text PDF