Comparison of six new antidepressants on isolated rat atria.

The effects of six new antidepressants were studied and compared as to their electromechanical properties on isolated rat atria. All of the compounds reduced rate and amplitude of contractions, depressed atrial excitability and prolonged the sinus node recovery time. They also inhibited the amplitude of the slow contractions elicited by isoprenaline in K-depolarized atria.

Intraarticular progesterone: effects of a local treatment for rheumatoid arthritis.

The antiinflammatory effect of a single intraarticular injection of progesterone was investigated in 12 patients with rheumatoid arthritis. A local, but no systemic decline of inflammation was observed in 10 of them for at least one month. The average local scores of inflammation at Days 7, 14, 21 and 30 after injection were significantly lower than pretreatment scores (p less than 0.

[Experimental esophageal transsection. Application to the treatment of hemorrhage in portal hypertension].

Nineteen of twenty dogs undergoing experimental esophageal transection with mechanical suturing were followed up over 1 to 120 days by means of light and electron microscopy examinations to evaluate changes in suture line. Histology showed few reactions to the metallic clips, the absence of new vessel formation with early healing from the 4th day, development of collagen fascicles after 1 week and consolidation after 2 weeks with reparation by the end of 1st month. Stability of healing process was apparent between 3 and 4 months, without evidence of stenosis due to scar tissue.

Electrophysiological effects of 5-hydroxypropafenone on guinea pig ventricular muscle fibers.

The effects of 5-hydroxypropafenone (5-OH-P), the main metabolite of propafenone, were studied in guinea pig papillary muscles obtained from untreated animals and from animals pretreated with 5-OH-P, 3 mg/kg for 24 days. In untreated muscles perfused with 2.7 and 5.

Comparative effects of oxodipine and nifedipine in the isolated guinea-pig heart.

The electromechanical effects of 2 dihydropyridines, oxodipine (OXD) and nifedipine, were compared on isolated guinea-pig atrial and ventricular muscle fibres. Intracardiac conduction times were measured in the Langendorff-perfused guinea-pig heart. On isolated atria OXD and nifedipine produced a dose-dependent decrease in rate and amplitude of contractions, the negative inotropic effect being accompanied by a shortening of the time to peak tension and time for total contraction.

Effects of 5-hydroxy-propafenone in guinea-pig atrial fibres.

The effects of 5-hydroxy-propafenone (5-OH-P), an active metabolite of propafenone, were studied on isolated atrial muscle fibres obtained from non-treated guinea-pigs and from animals pretreated with 5-OH-P, 3 mg kg-1, for 28 days. In untreated atria 5-OH-P, 10(-8) M-10(-4) M, produced a dose-dependent decrease in amplitude and df/dtmax and reduced the amplitude of the slow contractions induced by isoprenaline and histamine in high K+ media. 5-OH-P also produced a dose-dependent decrease in atrial rate, prolonged the sinus node recovery time and reduced the maximum chronotropic responses to isoprenaline.

Electrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atria.

The effects of amoxapine (10(-7)-10(-4) M) have been studied in rat atrial fibres obtained from untreated animals and animals pretreated for 28 days with amoxapine (10 mg kg-1, i.p.).

Negative inotropic effect of somatostatin in guinea-pig atrial fibres.

The effect of somatostatin (SS, 1 X 10(-7) M-5 X 10(-6) M) was studied on the electrical and mechanical properties of isolated atria of the guinea-pig. On spontaneously beating right atria, SS produced a dose-dependent negative inotropic effect which was accompanied by a decrease in atrial rate and a prolongation of the sinus node recovery time. In electrically driven left atria, SS produced a dose-dependent negative inotropic effect which occurred concomitantly with a decrease in the amplitude and duration of the plateau phase of the action potential of atrial fibres.