Hyperhomocysteinemia and other inherited prothrombotic conditions in young adults with a history of ischemic stroke.

Background And Purpose: The mechanisms of ischemic stroke in young adults are poorly understood. During the last years, several studies suggested a role for genetic factors predisposing to thrombophilia and for moderate hyperhomocysteinemia in this setting.

Methods: We evaluated in 132 consecutive patients (66 males, 66 females; mean+/-SD age, 38.