[Takayasu's disease. A review of the literature. A study of a familial case of Takayasu's arteritis and the possible associations with type-1 diabetes mellitus].

After a brief review of the literature on Takayasu's disease with particular emphasis on its relationship with the HLA system, the case of a mother and daughter both suffering from Takayasu's type systemic arteritis is presented with particular reference to a possible association with type-I diabetes mellitus (IDDM) in the light of the patient's HLA typing results.

Mortality among pyrite miners with low-level exposure to radon daughters.

Mortality among pyrite miners with low-level exposure to radon daughters. Scand J Work Environ Health 14 (1988) 280-285. A cohort mortality study was conducted with regard to a pyrite mine located in central Italy.

[Primary intestinal lymphomas. Review of the literature apropos of a clinical case].

A rare case of primary lymphoma of the bowel in a 26 year old woman is reported and the complex problems of diagnosis and treatment are examined. The importance of establishing the primary or secondary nature of this tumour of the small bowel is emphasised. This is because primary intestinal tumours require the most radical treatment possible even in advanced stages of the disease in order to avoid complications and to identify the areas involved in the proliferative process.

Bifid ureter with blind-ending branch.

A patient with a blind-ending branch of bifid ureter, one of the rarest anomalies in the upper urinary tract, is described.

[Primary hyperaldosteronism due to adrenocortical carcinoma. A clinical case report].

A rare case of primary hyperaldosteronism due to corticosuprarenal carcinoma is presented. The case was treated by suprarenalectomy and is currently under antiblastic treatment with mitotane (o-p'DDD). The clinical and endocrinological elements for differential diagnosis from the much more common suprarenal adenomas are examined in particular detail.

Mathematical model of muscular fatigue. Part III. Classification of muscular fibres versus metabolism of exhaustion.

In order to modelize muscular fatigue, use and depletion of energizing stores are incorporated in the previously elaborated model. The role of muscle glycogen is crucial in sustained muscular contractions. Two patterns of muscular exhaustion are described: one is related to glycogen depletion (S and FR fibres) and the other to an unphysiological drop in ATP concentrations (FF fibres).

[Acquired immunodeficiency syndrome. Review of the literature. Apropos of a pre-AIDS case in a heroin addict].

The Authors, after a review of the latest reports on ethiology, pathology and clinical aspects of acquired immunodeficiency syndrome (AIDS) and of linphadenopathyc syndrome (LAS or pre-AIDS), describe a case of pre-AIDS syndrome in a heroin addict characterized by typical symptoms, histological, serological and immunological patterns.

Mathematical model of muscular fatigue. II. Changes of metabolites level and of force during exercise in relation to a fatigability parameter.

In order to study muscular fatigue, a mathematical model allowing the simulation of changes of metabolites level and of force during exercise in human muscle is built. It results from the association of two previous models and from the introduction of two parameters (pH and ATP concentration) influencing directly the muscular force and of the fatigability parameter (A) which characterizes the oxidative capacity of a given fibre. Simulations of physiological conditions of exercise and recovery allow one to bring out a classification of muscular fibres in terms of the fatigability parameter.

[Weber-Christian disease with systemic involvement. Apropos of a case of histiocytic cytophagous panniculitis].

A case of systemic Weber-Christian disease involving the liver and medulla, with pancytopenia and disseminated intravascular coagulation (DIC) is reported. Clinical and histopathological diagnostic criteria are stressed. Post-mortem findings are described.

[An example of local thermodynamic equilibrium: delayed diffusion. Application to the calcium cycle in skeletal striated muscle fibers].

The binding of a molecule with a motionless support gives rise to a noticeable decrease of the diffusion coefficient. In a muscular fiber, calcium traps involve delayed diffusion. We compute the calcium concentration according to the fiber frequency excitation.

[The force-excitation relation in a striated skeletal muscle fiber].

Generalizing the sliding filaments model by the introduction of the calcium cycle, we get a relation between force, nervous excitation and contraction velocity.

Effect of subtoxic amounts of furan, acetylfuran and methylene chloride on some serum enzymes of rat.

Serum transaminases (GOT and GPT) and ornithincarbamyltransferase (OCT) were determined in rats treated with subtoxic doses of furan, acetylfuran, and methylene chloride. Significant increases of all enzymes were observed in methylene chloride treated rats, while only GOT increased in rats treated with acetylfuran and with furan + methylene chloride. Calculation of the GOT/GPT ratios indicated a pattern of toxic hepatitis only for rats treated with acetylfuran and furan + methylene chloride.

Human locomotion analysis: determination of muscular forces and nervous orders.

This study gives a modelization of gait which connects the kinematic and mechanical parameters of the motion with the characteristic ones of the muscular contraction (F, l, i, y). The problem, formulated from the equations of the motion related to a standard human being, is solved in terms of a minimization problem, taking into account the anatomical, physiological and energetic constraints of this motion by means of numerical calculations on a computer I.B.

Mathematical model of muscular fatigue. I. Metabolite level changes during exercises of different intensities.

To quantify muscular fatigue we study by a mathematical modelization the changes of the levels of ATP and various metabolites, and of the oxygen uptake with the intensity of a requested muscular exercise. The proposed model is consistent with the main phenomena experimentally observed during exercises; it allows also one to extrapolate these experimental results to any condition and to simulate exercise-complete and/or incomplete recovery cycles. The lactate kinetics allows one particularly to justify the empirical optimization of rest rhythms during exercises of long duration.

Construction, mathematical study and numerical simulation of a calcium turnover model during skeletal muscle contraction.

Starting from recent physiological data we establish a first order non-linear differential system which models the calcium turnover during skeletal muscular contraction. We describe the methods allowing one to calculate with a computer the non-experimentally directly-measured initial conditions. In order to ensure the consistency of the system with physiology we prove the positivity, a priori inequalities and both the existence and the uniqueness of the solutions.

[Delivery by cesarean section under general anesthesia and the neurobehavioral assessment of the newborn infant].

The problem of the effects on newborns of the anaesthetics administered to the mother has been reviewed. For research purposes Pentothal, widely used for induction in Caesarean section was considered. In spite of the presence of fair quantities of this drug, as demonstrated by foetal blood withdrawn from the umbilical cord, the newborns examined and submitted to painstaking neuro-behavioral assessment using Brazelton's method, did not show any signs of neurological impairment nor diversity in behaviour compared to a control group.

[Alterations of ventricular repolarization at rest, in young asymptomatic subjects. Diagnostic and predictive value of non-invasive methods].

In 34 asymptomatic subjects, aged 16 to 39 years, with clearcut abnormalities of ventricular repolarization on resting electrocardiogram, a forced hyperventilation and maximal exercise test were performed. The stress test was repeated, using the same protocol, after sublingual administration of nitroglycerin (0.3 mg) and of i.