Publications by authors named "Valentina Zullo"
Treatment with proton pump inhibitors is associated with secondary bacterial infections and sepsis in patients with COVID-19: a retrospective analysis of their joint impact on in-hospital prognosis.
Vanessa Bianconi Massimo R Mannarino Filippo Figorilli Federica Ricciutelli Stefania De Carlo Valentina Zullo
Ann Med
December 2024
Article Synopsis
- Secondary bacterial infections (SBIs) are linked to worse hospital outcomes for COVID-19 patients, with prior treatment using proton pump inhibitors (PPIs) increasing the risk of these infections.
- In a study of 1,087 hospitalized COVID-19 patients, 41% were on PPIs prior to admission, leading to higher rates of SBIs (18%) and secondary bacterial sepsis (SBS) (20%).
- PPI treatment was associated with a significantly greater risk of developing SBIs and SBS, which in turn increased the likelihood of ICU admissions or in-hospital deaths, highlighting the need for cautious PPI use in these patients.
Deep vein thrombosis (DVT) in critically ill patients still represents a clinical challenge. The aim of the study was to investigate whether a systematic ultrasound (US) screening might improve the management of the antithrombotic therapy in intensive care unit (ICU). In this non-randomized diagnostic clinical trial, 100 patients consecutively admitted to ICU of the University Hospital of Perugia were allocated either in the screening group or in the control group.
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