Publications by authors named "Valentina Zollet"
Article Synopsis
- Ischemia/reperfusion injury (IRI) occurs when blood flow is restored after a period of interrupted supply, leading to inflammatory responses and neutrophil recruitment that release NETs (neutrophil extracellular traps).
- In a study on pig forelimbs, researchers examined the effects of different durations of ischemia (1 hour vs. 9 hours) and monitored various indicators of tissue damage and NET formation.
- Findings indicated that longer ischemia worsens damage, with a significant increase in NETs and citrullinated fibrinogen levels in the 9-hour ischemia group compared to the 1-hour group, highlighting the detrimental role of NETs in IRI.
The blockade of the CD40/CD40L immune checkpoint is considered essential for cardiac xenotransplantation. However, it is still unclear which single antibody directed against CD40 or CD40L (CD154), or which combination of antibodies, is better at preventing organ rejection. For example, the high doses of antibody administered in previous experiments might not be feasible for the treatment of humans, while thrombotic side effects were described for first-generation anti-CD40L antibodies.
View Article and Find Full Text PDFNeutrophil released peptidyl arginine deiminase 4 (PAD4) converts arginine residues on plasma proteins into citrulline. Here, we developed an assay to quantify citrullinated fibrinogen. We employed a biotin-conjugated phenylglyoxal (biotin-phenylglyoxal (PG)) compound that selectively labels citrulline.
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