Publications by authors named "Valentina Woronzow"
Cellular senescence is characterized by replication arrest in response to stress stimuli. Senescent cells accumulate in aging tissues and can trigger organ-specific and possibly systemic dysfunction. Although senescent cell populations are heterogeneous, a key feature is that they exhibit epigenetic changes.
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- Cells in the developing human brain undergo genetic and epigenetic changes that may lead to neurogenetic disorders, influenced by the mobilization of transposable elements (TEs) like LINE-1 (L1).
- Research shows that mobile TEs, such as AluY and SVA families, use L1 activity during development, potentially affecting neural cell variability.
- A study using representational difference analysis and deep sequencing found unique SVA integrations across different brain regions, which helped construct a phylogenetic tree and supported evolutionary patterns in neurodevelopment.