Publications by authors named "Valentina Semenikhina"
Article Synopsis
- Enzymatic inhibition of histone deacetylase (HDAC) is a promising strategy for cancer treatment, leading to the development of new amide derivatives.
- Several of these compounds demonstrated strong HDAC inhibitory effects, with low IC(50) values in nanomolar ranges when tested on HeLa cells.
- The novel compounds, particularly one called (E)-N-[6-(hydroxyamino)-6-oxohexyl]-3-(7-quinolinyl)-2-propenamide, showed impressive results in vivo, significantly increasing the lifespan of mice with leukemia.
A series of new N-hydroxyguanidines were synthesized and tested for electron acceptor activity on bovine milk xanthine oxidase using xanthine as reducing substrate. Manual inspection of the structure-activity data revealed that molecules containing nitro groups ("set A") show a different structure-activity relationship pattern compared to non-nitro compounds ("set B"). Accordingly separate QSAR models were built and validated for the two sets.
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