Publications by authors named "Valentina Saba"
Article Synopsis
- * A study analyzed 4,685 sporadic FTD cases and found significant genetic variants at the MAPT and APOE loci that increase the risk for the disease, indicating potential genetic overlap with other neurodegenerative diseases.
- * The genetic risk factors appear to vary by population, with MAPT and APOE associations predominantly found in Central/Nordic and Mediterranean Europeans, suggesting a need for further research into these population-specific features for better understanding of sporadic FTD.
Article Synopsis
- The study aimed to explore how traditional stroke risk factors affect the likelihood of intracerebral hemorrhage (ICH) based on age.
- Researchers conducted a case-control analysis involving 3,492 ICH patients and an equal number of stroke-free controls from a multi-center study in Italy.
- Results indicated that untreated hypertension significantly increases ICH risk more in younger individuals, while untreated hypercholesterolemia's impact decreases with age; untreated diabetes and high alcohol intake were only risky for older adults.
Brain functional disruption and cognitive shortfalls as consequences of neurodegeneration are among the most investigated aspects in current clinical research. Traditionally, specific anatomical and behavioral traits have been associated with neurodegeneration, thus directly translatable in clinical terms. However, these qualitative traits, do not account for the extensive information flow breakdown within the functional brain network that deeply affect cognitive skills.
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