Publications by authors named "Valentina S Shateeva"
Article Synopsis
- Reactive oxygen species (ROS) from NADPH oxidase (NOX) are crucial for regulating blood vessel contraction during early development, and neonatal hypoxia alters this function.
- Normobaric hypoxia exposure in rat pups leads to significant changes in how NOX-derived ROS influence blood vessel contractions, particularly when triggered by specific agonists.
- Understanding these mechanisms may highlight risks for disorders due to hypoxia during the perinatal period, although the exact programming effects of such conditions remain largely unexplored.
Reactive oxygen species (ROS) produced by NADPH oxidases (NOX, a key source of ROS in vascular cells) are involved in the regulation of vascular tone, but this has been explored mainly for adult organisms. Importantly, the mechanisms of vascular tone regulation differ significantly in early postnatal ontogenesis and adulthood, while the vasomotor role of ROS in immature systemic arteries is poorly understood. We tested the hypothesis that the functional contribution of NADPH oxidase-derived ROS to the regulation of peripheral arterial tone is higher in the early postnatal period than in adulthood.
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