Publications by authors named "Valentina Rezic"
Article Synopsis
- Acacetin, apigenin, chrysin, and pinocembrin are flavonoids found in foods like parsley and honey, which can influence the CYP3A4 enzyme that metabolizes many drugs.
- The study aimed to analyze how these flavonoids inhibit the CYP3A4 enzyme, their binding properties, and if they act as pseudo-irreversible inhibitors, using nifedipine oxidation as a measure.
- All flavonoids inhibited CYP3A4, with chrysin being the most effective, but none exhibited pseudo-irreversible inhibition, highlighting the need for clinical evaluation of potential food-drug interactions.
