Publications by authors named "Valentina Pechnikova"
Article Synopsis
- Cardiac involvement is crucial in determining the prognosis for systemic amyloidosis patients, with a study analyzing 98 patients focusing on which amyloid types impact the heart most significantly.
- The study categorized patients into two groups: those diagnosed via endomyocardial biopsies (EMBs) and those diagnosed post-mortem through autopsy, revealing varying types of amyloidosis in each group.
- Findings indicated a notable underdiagnosis of ATTR amyloidosis, particularly in elderly patients, and highlighted that AL kappa amyloidosis leads to more severe amyloid deposits and worse outcomes.
The gut microbiota plays an essential role in maintaining immune homeostasis and influencing the immune landscape within the tumor microenvironment. This review aims to elucidate the interactions between gut microbiota and tumor immune dynamics, with a focus on colorectal cancer (CRC). The review spans foundational concepts of immuno-microbial interplay, factors influencing microbiome composition, and evidence linking gut microbiota to cancer immunotherapy outcomes.
View Article and Find Full Text PDFAmyloidosis is one of the rare systemic illnesses characterized by the deposition of amyloid fibrils in various organs and tissues. There is a common point between COVID-19 and systemic amyloidosis regarding the multiorgan involvement in the pathological process which leads to a heightened risk for severe morbidity and mortality in amyloidosis patients who contracted COVID-19. We performed a pathomorphological analysis of the autopsy records of 22 patients who had COVID-19 and pre-existing systemic amyloidosis.
View Article and Find Full Text PDFLopes−Maciel−Rodan syndrome (LOMARS) is an extremely rare disorder, with only a few cases reported worldwide. LOMARS is caused by a compound heterozygous mutation in the HTT gene. Little is known about LOMARS pathogenesis and clinical manifestations.
View Article and Find Full Text PDFObjective: Serrated colorectal lesions are a group of colonic lesions with a serrated (saw-tooth) profile of the surface epithelium and crypts, and peculiar molecular and genetic developmental mechanisms that are incompletely understood. These formations cause concern due to their premalignant potential.
Aim: The review is dedicated to serrated lesions of colon and appendix.
Background: Gallstone disease is a burden affecting about 15% percent of the population around the world. The complications of gallstone disease are numerous and many require emergency care. Severe complications are not uncommon and require special attention, as lethal outcome is possible.
View Article and Find Full Text PDFObjective: The molecular mechanisms of bladder cancer development and progression are not clear. Bladder cancer is an important focus for epidemiological studies and understanding clinical implications.
Goal: The primary aim of prevention is achieved by limiting exposure to non-genetic risk factors, such as smoking, diet, arsenic in drinking water, or aromatic amines at work or elsewhere.