Publications by authors named "Valentina P Sebastian"
An important virulence trait of serovar Typhimurium ( Typhimurium) is the ability to avoid the host immune response, generating systemic and persistent infections. Host cells play a crucial role in bacterial clearance by expressing the enzyme heme oxygenase 1 (Hmox1), which catalyzes the degradation of heme groups into Fe, biliverdin, and carbon monoxide (CO). The role of Hmox1 activity during Typhimurium infection is not clear and previous studies have shown contradictory results.
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- * In a study with mice, it was found that neutrophils are the primary source of interleukin-10 (IL-10), which helps reduce lung injury and improve survival during an acute lung infection.
- * The research identified two distinct subpopulations of neutrophils with different IL-10 production profiles, suggesting that these cells are vital to controlling lung damage and managing the immune response.
Article Synopsis
- Paneth cells are special cells in the small intestine that help protect against germs and keep the gut healthy.
- When they don't work correctly, it can lead to diseases like Crohn's disease and infections.
- In a study with a specific type of mice (IL-10-/-), scientists found that these mice had messed-up Paneth cells and were more likely to get sick from germs, suggesting that a protein called IL-10 is important for keeping Paneth cells healthy.
Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450. The enzymatic reaction catalyzed by HMOX1 generates Fe, biliverdin and CO. It has been shown that HMOX1 activity and the by-product CO can downmodulate the damaging immune response in several models of intestinal inflammation as a result of pharmacological induction of HMOX1 expression and the administration of non-toxic amounts of CO.
View Article and Find Full Text PDFCigarette smoking is a major risk factor for gastrointestinal disorders, such as peptic ulcer, Crohn's disease (CD), and several cancers. The mechanisms proposed to explain the role of smoking in these disorders include mucosal damage, changes in gut irrigation, and impaired mucosal immune response. Paradoxically, cigarette smoking is a protective factor for the development and progression of ulcerative colitis (UC).
View Article and Find Full Text PDFInflammatory bowel disease (IBD) includes a set of pathologies that result from a deregulated immune response that may affect any portion of the gastrointestinal tract. The most prevalent and defined forms of IBD are Crohn's disease and ulcerative colitis. Although the etiology of IBD is not well defined, it has been suggested that environmental and genetic factors contribute to disease development and that the interaction between these two factors can trigger the pathology.
View Article and Find Full Text PDFAim: To study the association between exposure to Salmonella enterica (SE) and Crohn's disease (CD) and its clinical implications in Chilean patients.
Methods: Ninety-four unrelated Chilean CD patients from CAREI (Active Cohort Registry of Inflammatory Bowel Disease) presenting to a single inflammatory bowel disease (IBD) unit of a University Hospital were prospectively included in this study. A complete clinical evaluation, including smoking history, was performed at the initial visit, and all the important data of clinical evolution of CD were obtained.