Publications by authors named "Valentina Nale"
Article Synopsis
- Multiple sclerosis (MS) is a diverse condition with varying symptoms and treatment responses, prompting a study on its genetic causes related to disease activity over time.
- Researchers analyzed genetic data from two groups of relapsing-remitting MS patients, examining their genomes and specific gene interactions in brain and lymphocyte tissues to identify key genetic variants and pathways involved in MS.
- The study found 23 genetic variants and 223 associated genes, with significant genes such as PON2 and ILRUN linked to oxidative stress and immune modulation, revealing shared and tissue-specific mechanisms driving MS disease activity.
Introduction: Single-cell (SC) gene expression analysis is crucial to dissect the complex cellular heterogeneity of solid tumors, which is one of the main obstacles for the development of effective cancer treatments. Such tumors typically contain a mixture of cells with aberrant genomic and transcriptomic profiles affecting specific sub-populations that might have a pivotal role in cancer progression, whose identification eludes bulk RNA-sequencing approaches. We present scMuffin, an R package that enables the characterization of cell identity in solid tumors on the basis of a various and complementary analyses on SC gene expression data.
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