Publications by authors named "Valentina Kapustina"
One of the severe complications occurring because of the patient's intubation is tracheal stenosis. Its incidence has significantly risen because of the COVID-19 pandemic and tends only to increase. Here, we propose an alternative to the donor trachea and synthetic prostheses-the tracheal equivalent.
View Article and Find Full Text PDFPrevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID).
BMC Med
July 2022
Article Synopsis
- - The study investigated the prevalence of post-COVID-19 condition (PCC) in adults and children who were hospitalized after contracting COVID-19, using a defined WHO standard and conducting follow-ups at 6 and 12 months post-discharge.
- - Findings showed a PCC prevalence of 50% in adults and 20% in children at 6 months, decreasing to 34% and 11%, respectively, at 12 months; factors such as female sex and hypertension in adults, and neurological comorbidities in children were linked to higher PCC risk.
- - The results highlight the importance of monitoring for ongoing health issues following COVID-19, particularly in higher-risk groups, as a significant number of individuals experienced
Cell viability is the primary integrative parameter used for various purposes, particularly when fabricating tissue equivalents (, using bioprinting or scaffolding techniques), optimizing conditions to cultivate cells, testing chemicals, drugs, and biomaterials, Most of the conventional methods were originally designed for a monolayer (2D) culture; however, 2D approaches fail to adequately assess a tissue-engineered construct's viability and drug effects and recapitulate the host-pathogen interactions and infectivity. This study aims at revealing the influence of particular 3D cell systems' parameters such as the components' concentration, gel thickness, cell density, on the cell viability and applicability of standard assays. Here, we present an approach to achieving adequate and reproducible results on the cell viability in 3D collagen- and fibrin-based systems using the Live/Dead, AlamarBlue, and PicoGreen assays.
View Article and Find Full Text PDFRecurrence in hepatocellular carcinoma (HCC) after conventional treatments is a crucial challenge. Despite the promising progress in advanced targeted therapies, HCC is the fourth leading cause of cancer death worldwide. Radionuclide therapy can potentially be a practical targeted approach to address this concern.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated long-term symptoms in hospitalized COVID-19 patients, finding that 47.1% reported ongoing issues like fatigue, shortness of breath, and forgetfulness after discharge.
- Data was gathered from 2,649 patients in Moscow, focusing on their experiences 218 days post-discharge, showing that while many cases were mild, some required significant medical interventions.
- Female patients had a higher likelihood of persistent symptoms, particularly skin issues, while asthma was linked to neurological and mood-related changes.
Background: The epidemiology, clinical course, and outcomes of patients with coronavirus disease 2019 (COVID-19) in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically diagnosed COVID-19 in real-life settings is lacking.
Methods: We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow between 8 April and 28 May 2020.