Publications by authors named "Valentina K Yu"
This study investigated the effects of aseptic inflammation and heavy metal exposure on immune responses, as well as the potential immunomodulatory properties of the newly synthesized 1-[1-(2,5-dimethoxyphenyl)-4-(naphthalene-1-yloxy)but-2-ynyl]-4-methylpiperazine complexed with β-cyclodextrin (β-CD). Aseptic inflammation was induced by a subcutaneous injection of turpentine in rats, while heavy metal exposure was achieved through a daily administration of cadmium chloride and lead acetate. The levels of immune cell populations, including cytotoxic T lymphocytes (CTL), monocytes, and granulocytes, were assessed in the spleen.
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- Novel 3,7-bicycl[3.3.1]bispidines were synthesized, featuring different substituents like imidazolpropyl and Boc groups, and tested for their effectiveness as seed protectors for various wheat varieties.
- Using N-substituted piperidones and strong acid condensation, the targeted compounds were created and complexed with β-cyclodextrin to enhance their growth-stimulating properties.
- The growth assays indicated significant root and shoot growth increases in certain wheat strains due to these complexes, demonstrating that the specific chemical structure of the bispidines influences their effectiveness in promoting plant growth.
Polyamine (PA) catabolism is often reduced in cancer cells. The activation of this metabolic pathway produces cytotoxic substances that might cause apoptosis in cancer cells. Chemical compounds able to restore the level of PA catabolism in tumors could become potential antineoplastic agents.
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