Morphology of Lymphoid Tissue in the Lungs of Guinea Pigs Infected with against the Background of Vaccine Immunity and the Action of Betulin and Its Derivatives.

Tuberculosis caused by is a serious problem for animal and human health worldwide. A promising concept for the design of anti-tuberculosis drugs is the conjugation of an immunogenic fraction isolated from bacterial vaccines with a stimulating component. Taking this principle as a basis, conjugates based on BCG antigens with betulin and its derivatives (betulonic and betulinic acids) were designed.