Publications by authors named "Valentina E Diaz"
Background: Emerging research suggests adverse childhood experiences (ACEs) have long-lasting impacts on adult brain health, but few studies investigate these effects in older adults. The present study examined ACEs and their relationships to late-life cognitive and mental health among older adults living in the San Francisco Bay Area.
Method: 102 cognitively unimpaired older adults [mean age = 75, 58% female, 75% White, 25% Latino, mean education = 17 years] were enrolled in UC San Francisco's Alzheimer's Disease Research Center.
Article Synopsis
- The rise of autoimmune diseases calls for new therapies, but there's a lack of long-term evaluation methods for these treatments.
- Researchers used advanced techniques to analyze the unique patterns of autoantibodies in individuals, identifying stable "autoreactomes" that serve as immunological fingerprints.
- Their findings suggest that therapies targeting B cell maturation antigen (BCMA) can significantly change these autoreactomes, implying that BCMA-based treatments might be effective for difficult-to-treat autoimmune conditions.
Article Synopsis
- The rise of autoimmune diseases and related disorders is significant globally, but the underlying causes are still unclear, and there is a lack of comprehensive methods to evaluate new immunomodulatory treatments over time.
- Researchers used advanced PhIP-Seq technology to study how autoantibody profiles, which are unique to each individual, change in health and disease, identifying a stable immunological fingerprint known as the "autoreactome."
- The study found that certain therapies, specifically those targeting B-Cell Maturation Antigen (BCMA), have a major impact on autoantibody profiles, while others like anti-CD19 and CD-20 have minimal influence, suggesting BCMA-targeted therapies may be more effective in treating autoantibody-mediated diseases.
Physical activity (PA) is linked to better cognitive and brain health, though its mechanisms are unknown. While brain iron is essential for normal function, levels increase with age and, when excessive, can cause detrimental neural effects. We examined how objectively measured PA relates to cerebral iron deposition and memory functioning in normal older adults.
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