Publications by authors named "Valentina Dolcemascolo"
Article Synopsis
- The study aimed to identify early indicators of relapse and outcomes in pediatric patients with myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD).* -
- Researchers analyzed data from 75 children, finding differences in disease presentation based on age; younger patients were more likely to present with acute disseminated encephalomyelitis, while older patients saw more cases of optic neuritis.* -
- Results highlighted specific early treatment factors, such as starting immunotherapy within 7 days or prolonged corticosteroid use, as associated with lower relapse risks; 21.1% of patients had moderate to severe disability at final follow-up, particularly among those with relapsing disease.*
Objective: The aims of the present study were: (1) to review the literature on long-lasting cognitive sequelae in children treated for Posterior Fossa Tumor and (2) to investigate anatomic functional relations in a case series of 7 children treated for PFT using magnetic resonance imaging (MRI) post-processing methods.
Methods: We retrospectively analyzed MRIs of children who underwent complete surgical resection of PFT and performed extensive neuropsychological evaluation. Tumor, ventricular volumes, and VPS insertion site were drawn on T1 volumetric MRI scans and normalized to a pediatric template.
Article Synopsis
- Cerebellar tumor survivors often face neuropsychological deficits linked to changes in brain networks, prompting a pilot study to explore the relationship between cerebellar white matter structure and cognitive function in children long-term after their treatment.
- Using diffusion tensor imaging (DTI) in pediatric patients with posterior fossa tumors, researchers examined various brain fiber tracts and assessed cognitive performance through standardized tests.
- Results from seven evaluated patients indicated cognitive impairments, particularly in memory, with significant correlations found between cognitive scores and specific cerebellar tracts, suggesting the integrity of these pathways may influence long-term cognitive outcomes.
Hemolytic uremic syndrome (HUS) is defined by the simultaneous occurrence of hemolytic anemia, thrombocytopenia, and acute kidney injury due to thrombotic microangiopathy (TMA) mainly occurring in renal and cerebral microvessels. Although the most common cause of HUS in children is Shiga toxin-producing , atypical forms in which Shiga toxin is not the trigger may occur. Research over the last few years has shown that complement dysregulation secondary to mutations of genes coding for proteins involved in the regulation of the alternative pathway of complement account for most forms of atypical HUS (aHUS).
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