Transient shape morphing of active gel plates: geometry and physics.

The control of shape in active structures is a key problem for the realization of smart sensors and actuators, which often draw inspiration from natural systems. In this context, slender structures, such as thin plates, have been studied as a relevant example of shape morphing systems where curvature is generated by in-plane incompatibilities. In particular, in hydrogel plates these incompatibilities can be programmed at fabrication time, such that a target configuration is attained at equilibrium upon swelling or shrinking.

Multi-physics interactions drive VEGFR2 relocation on endothelial cells.

Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) is a pro-angiogenic receptor, expressed on endothelial cells (ECs). Although biochemical pathways that follow the VEGFR2 activation are well established, knowledge about the dynamics of receptors on the plasma membrane remains limited. Ligand stimulation induces the polarization of ECs and the relocation of VEGFR2, either in cell protrusions or in the basal aspect in cells plated on ligand-enriched extracellular matrix (ECM).