Invasive electrophysiological evaluation and ablation in patients with asymptomatic ventricular pre-excitation persistent at exercise stress test.

Aims: In patients with asymptomatic ventricular pre-excitation (VPE) persistent at exercise stress test, this study evaluates the proportion of cases with adverse conduction properties of the atrioventricular accessory pathway (AP) at invasive electrophysiological study and the long-term follow-up after they received treatment according to pre-determined criteria.

Methods And Results: Over 10 years, asymptomatic patients with VPE persistent at exercise stress test referred for invasive electrophysiological evaluation including isoproterenol (IPN) infusion were included. Ablation was planned if they had at least one of the following criteria: (i) shortest pre-excited R-R interval (SPERRI) ≤250 ms and/or (ii) inducible atrioventricular re-entrant tachycardia (AVRT).