Publications by authors named "Valentina Barbui"
Background And Aim: Nowadays, in Italy, the nursing profession has suffered important changes in response to the needs of citizens' health and to improve the quality of the health service in the country. At the basis of this development there is an increase of the nurses' knowledge, competencies and responsibilities. Currently, the presence of nurses who have followed post-basic training paths, and the subsequent acquisition of advanced clinical knowledge and specializations, has made it essential for the presence of competencies mappings for each specialty, also to differentiate them from general care nurses.
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- - ITF2357, a histone deacetylase inhibitor, shows strong cytotoxic effects against multiple myeloma and is currently being tested in clinical trials for this condition.
- - Gene expression profiling of myeloma cells treated with ITF2357 revealed significant changes, identifying 140 and 574 up-regulated genes and 102 and 556 down-modulated genes after 2 and 6 hours, with key changes in genes related to transcription and apoptosis.
- - The drug specifically decreased the expression of the interleukin-6 receptor alpha (CD126) and affected associated signaling pathways, suggesting ITF2357 disrupts mechanisms crucial for myeloma cell growth and survival.
Background Aims: Human multipotent mesenchymal stromal cells (hMSC) are considered good candidates for a growing spectrum of cell therapies. We have validated a protocol that makes use of the washouts of discarded collection sets, left over at the end of the filtration of bone marrow (BM) explants performed for hematopoietic stem cell (HSC) transplantation.
Methods: The method consists of direct plating of cells without density-gradient isolation followed by two detachment steps and expansion in 5% human platelet lysate (hPL).