Publications by authors named "Valentin Legras"
Article Synopsis
- An interactive tool was created to assist in designing oral solid dosage formulations, allowing users to explore and compare the physical, bulk, and mechanical properties of various materials.
- The tool integrates multiple data sources into a comprehensive table and supports workflows like exploring materials and searching for similar APIs and excipients.
- It emphasizes empowering formulation scientists to explore diverse options rather than strictly relying on mathematical calculations, with practical examples demonstrating its application in material selection.
Physiologically based pharmacokinetic (PBPK) models of entrectinib and its equipotent metabolite, M5, were established in healthy adult subjects and extrapolated to pediatric patients to predict increases in steady-state systemic exposure on co-administration of strong and moderate CYP3A4 inhibitors (itraconazole at 5 mg/kg, erythromycin at 7.5-12.5 mg/kg and fluconazole at 3-12 mg/kg, respectively).
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