Publications by authors named "Valentin Aebischer"
Background And Objective: Erosions of the skin and mucous membranes with epidermal dysmaturation are a known side effect of cytostatic chemotherapy regimens and can also be observed during low-dose methotrexate (MTX) therapy. The study aimed to delineate the clinical and histopathological alterations.
Patients And Methods: A database search of the archive for dermatopathology was conducted, identifying 22 patients who developed epidermal dysmaturation on low-dose MTX.
Background: Next-generation sequencing (NGS) is the most commonly used method for determining mutational status in patients with advanced melanoma. Automated PCR-based methods, such as the Idylla system, are increasingly used for mutation diagnostics, but it is unclear what impact the choice of diagnostic method has on the management of melanoma.
Objectives: To compare the concordance rate of V600 mutational analysis using Idylla and NGS and to analyze the technical and clinical turnaround time.
Tumor-associated antigens (TAAs) are potential targets for T cell-based immunotherapy approaches in cutaneous melanoma. BNT111, an investigational lipoplex-formulated mRNA-based therapeutic cancer vaccine encoding melanoma TAAs NY-ESO-1, tyrosinase, MAGE-A3, and TPTE, is undergoing clinical testing in adults. Expression of these TAAs in pediatric melanoma is unclear but is a prerequisite for feasibility of this treatment approach in children with melanoma.
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- * In a study comparing 25 pediatric melanoma samples to those from young and older adults, researchers found significantly lower levels of PRAME expression in pediatric cases, indicating age-dependency in marker expression.
- * The findings suggest that relying on PRAME as a diagnostic or therapeutic option in pediatric melanoma may be problematic due to its low expression, highlighting the need for tailored approaches in treating younger patients.
Background And Objectives: Due to frailty, dermatosurgery in the elderly is preferably performed under tumescent local anesthesia, but data is limited. The aim was to evaluate tumescent local anesthesia for skin cancer surgery in the elderly with focus on clinical benefits (treatment processes, pain management) and local postoperative complication risk.
Patients And Methods: Investigation of patients ≥ 75 years with inpatient head and neck skin cancer surgery under tumescent local anesthesia.
The increasing number of melanoma patients makes it necessary to develop best possible strategies for prognosis assessment in order to recommend appropriate therapy and follow-up. The prognostic significance of tumor cell pigmentation has not been fully elucidated. Hematoxylin and eosin (H&E)-stained sections of 775 melanomas diagnosed between 2012 and 2015 were independently assessed for melanin pigment abundance by two investigators, and the impact on melanoma-specific survival was calculated.
View Article and Find Full Text PDFA 59-year-old man presented with a growing tumor on the glans penis, which we excised. Histologically, there was an acanthotic epidermis under which the papillary dermis was filled with foamy macrophages, best seen in a CD 68 stain. Verruciform xanthoma was diagnosed.
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- The study examines systemic side effects in elderly patients (≥75 years) undergoing skin tumor surgery with tumescent local anesthesia due to increased procedures in this demographic.
- A total of 782 patients were examined, revealing a 10.2% incidence of systemic complications, primarily hypertensive crises, with no life-threatening issues linked directly to the anesthesia.
- The findings indicate that while systemic complications can happen, surgery with tumescent local anesthesia is generally safe for elderly patients, helping to avoid risks associated with general anesthesia.