Synthesis and crystal structure of 2,9-di-amino-5,6,11,12-tetra-hydro-dibenzo[,]cyclo-octene.

The - form of di-amino-dibenzo-cyclo-octane (DADBCO, CHN) is of inter-est as a negative coefficient of thermal expansion (CTE) material. The crystal structure was determined through single-crystal X-ray diffraction at 100 K and is presented herein.

The anti-gender threat: An ethical, democratic, and scientific imperative for NIH research/ers.

Anti-gender campaigns in the United States and globally have promoted policies and legislation that significantly limit bodily autonomy for women, transgender, and nonbinary people. This attack on the human rights of women and gender-diverse communities not only reflects implicit and explicit bias but also detrimentally impacts population health and well-being. We outline the domestic and global rise of anti-gender campaigns and their deep historical connections to broader forms of discrimination and inequality to argue that there is an ethical, democratic, and scientific imperative to more critically center and contextualize gender in health research.

Functional Grading Between Soft-Magnetic Fe-Co/Fe-Ni Alloys and the Effect on Magnetic and Microstructural Properties.

Producing soft magnetic alloys by additive manufacturing has the potential to overcome cracking and brittle fracture issues associated with conventional thermomechanical processing. Fe-Co alloys exhibit high magnetic saturation but low ductility that makes them difficult to process by commercial methods. Ni-Fe alloys have good ductility and high permeability in comparison to Fe-Co, but they suffer from low magnetic saturation.

Studying Up from the Margins in a white-supremacist-cis-hetero-patriarchal-capitalist culture.

This article examines the citational politics of teaching, learning, and doing ethnographic projects that study up in medical anthropology by examining the references that are often cited, the ones that exist but are not widely circulated, and the gaps in between. I take a reflexive approach to understanding how my positionality shaped my path toward studying up. In so doing, I reveal the complex tensions of implementing ethnographic methods in spaces that are (intentionally) challenging to access while simultaneously being embedded within academic and social environments that are plagued by hierarchical power relations.

Crystal structures of polymerized lithium chloride and dimethyl sulfoxide in the form of {2LiCl·3DMSO} and {LiCl·DMSO} .

Two novel LiCl·DMSO polymer structures were created by combining dry LiCl salt with dimethyl sulfoxide (DMSO), namely, -poly[[chlorido-lithium(I)]-μ-(dimethyl sulfoxide)-κ :-[chlorido-lithium(I)]-di-μ-(dimethyl sulfoxide)-κ :], [LiCl(CHOS)] , and -poly[lithium(I)-μ-chlorido-μ-(dimethyl sulfoxide)-κ :], [LiCl(CHOS)] . The initial synthesized phase had very small block-shaped crystals (<0.08 mm) with monoclinic symmetry and a 2 LiCl: 3 DMSO ratio.

Trends in Siting of Metals in Heterometallic Nd-Yb Metal-Organic Frameworks and Molecular Crystals.

Several studies suggest that metal ordering within metal-organic frameworks (MOFs) is important for understanding how MOFs behave in relevant applications; however, these siting trends can be difficult to determine experimentally. To garner insight into the energetic driving forces that may lead to nonrandom ordering within heterometallic MOFs, we employ density functional theory (DFT) calculations on several bimetallic metal-organic crystals composed of Nd and Yb metal atoms. We also investigate the metal siting trends for a newly synthesized MOF.

Evidence of decoupling of surface and bulk states in Dirac semimetal CdAs.

Dirac semimetals have attracted a great deal of current interests due to their potential applications in topological quantum computing, low-energy electronic devices, and single photon detection in the microwave frequency range. Herein are results from analyzing the low magnetic () field weak-antilocalization behaviors in a Dirac semimetal CdAsthin flake device. At high temperatures, the phase coherence lengthfirst increases with decreasing temperature () and follows a power law dependence of∝.

Duoethnography as Transformative Praxis: Conversations about Nourishment and Coercion in the COVID-Era Academy.

This article introduces the feminist praxis of duoethnography as a way to examine the COVID era. As a group of diverse, junior, midcareer, and senior feminist scholars, we developed a methodology to critically reflect on our positions in our institutions and social worlds. As a method, duoethnography emphasizes the dialogical intimacy that can form through anthropological work.

Programmable Photoluminescence via Intrinsic and DNA-Fluorophore Association in a Mixed Cluster Heterometallic MOF.

A rapid and facile design strategy to create a highly complex optical tag with programmable, multimodal photoluminescent properties is described. This was achieved via intrinsic and DNA-fluorophore hidden signatures. As a first covert feature of the tag, an intricate novel heterometallic near-infrared (NIR)-emitting mesoporous metal-organic framework (MOF) was designed and synthesized.

Covert MOF-Based Photoluminescent Tags via Tunable Linker Energetics.

Optical anticounterfeiting tags utilize the photoluminescent properties of materials to encode unique patterns, enabling identification and validation of important items and assets. These tags must combine optical complexity with ease of production and authentication to both prevent counterfeiting and to remain practical for widespread use. Metal-organic frameworks (MOFs) based on polynuclear, rare earth clusters are ideal materials platforms for this purpose, combining fine control over structure and composition, with tunable, complex energy transfer mechanisms via both linker and metal components.

Kinetically Controlled Linker Binding in Rare Earth-2,5-Dihydroxyterepthalic Acid Metal-Organic Frameworks and Its Predicted Effects on Acid Gas Adsorption.

In the pursuit of highly stable and selective metal-organic frameworks (MOFs) for the adsorption of caustic acid gas species, an entire series of rare earth MOFs have been explored. Each of the MOFs in this series (RE-DOBDC; RE = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu; DOBDC = 2,5-dihydroxyterepthalic acid) was synthesized in the tetragonal space group 4/. Crystallized MOF samples, specifically Eu-DOBDC, were seen to have a combination of monodentate and bidentate binding when synthesized under typical reaction conditions, resulting in a contortion of the structure.

Rational Design of an Antimicrobial Peptide Based on Structural Insight into the Interaction of Initiation Factor 1 with Its Cognate 30S Ribosomal Subunit.

Bacterial infections continue to represent a major worldwide health hazard following the emergence of drug-resistant pathogenic strains. is an opportunistic pathogen causing nosocomial infections with increased morbidity and mortality. The increasing antibiotic resistance in has led to an unmet need for discovery of new antibiotic candidates.

Vaxign2: the second generation of the first Web-based vaccine design program using reverse vaccinology and machine learning.

Vaccination is one of the most significant inventions in medicine. Reverse vaccinology (RV) is a state-of-the-art technique to predict vaccine candidates from pathogen's genome(s). To promote vaccine development, we updated Vaxign2, the first web-based vaccine design program using reverse vaccinology with machine learning.

The nucleotide binding affinities of two critical conformations of Escherichia coli ATP synthase.

ATP synthase is essential in aerobic energy metabolism, and the rotary catalytic mechanism is one of the core concepts to understand the energetic functions of ATP synthase. Disulfide bonds formed by oxidizing a pair of cysteine mutations halted the rotation of the γ subunit in two critical conformations, the ATP-waiting dwell (αE284C/γQ274C) and the catalytic dwell (αE284C/γL276C). Tryptophan fluorescence was used to measure the nucleotide binding affinities for MgATP, MgADP and MgADP-AlF (a transition state analog) to wild-type and mutant F under reducing and oxidizing conditions.

Encoding Multilayer Complexity in Anti-Counterfeiting Heterometallic MOF-Based Optical Tags.

Optical tags provide a way to quickly and unambiguously identify valuable assets. Current tag fluorophore options lack the tunability to allow combined methods of encoding in a single material. Herein we report a design strategy to encode multilayer complexity in a family of heterometallic rare-earth metal-organic frameworks based on highly connected nonanuclear clusters.

Luminescent Properties of DOBDC Containing MOFs: The Role of Free Hydroxyls.

A novel metal-organic framework (MOF), Mn-DOBDC, has been synthesized in an effort to investigate the role of both the metal center and presence of free linker hydroxyls on the luminescent properties of DOBDC (2,5-dihydroxyterephthalic acid) containing MOFs. Co-MOF-74, RE-DOBDC (RE-Eu and Tb), and Mn-DOBDC have been synthesized and analyzed by powder X-ray diffraction (PXRD) and the fluorescent properties probed by UV-Vis spectroscopy and density functional theory (DFT). Mn-DOBDC has been synthesized by a new method involving a concurrent facile reflux synthesis and slow crystallization, resulting in yellow single crystals in monoclinic space group 2/.

Vaxign-ML: supervised machine learning reverse vaccinology model for improved prediction of bacterial protective antigens.

Motivation: Reverse vaccinology (RV) is a milestone in rational vaccine design, and machine learning (ML) has been applied to enhance the accuracy of RV prediction. However, ML-based RV still faces challenges in prediction accuracy and program accessibility.

Results: This study presents Vaxign-ML, a supervised ML classification to predict bacterial protective antigens (BPAgs).

Improvising Race: Clinical Trials and Racial Classification.

In this article, I explore how ethnicity codes are used in a prenatal trial in the United Kingdom. Here, ethnicity codes are generative objects that relationally cohere across staff, surveys and pregnant participants to create racial improvisations. I examine the origins and adaptations of ethnicity codes across three ethnographic and historical cases at micro and macro scales.

The Redistribution of Reproductive Responsibility: On the Epigenetics of "Environment" in Prenatal Interventions.

The rapidly shifting field of epigenetics has expanded scientific understanding of how environmental conditions affect gene expression and development. This article focuses on two ongoing clinical trials-one in the United States and one in the United Kingdom-that have used epigenetics as the conceptual basis for testing the relationship between nutrition and obesity during pregnancy. Drawing on ethnographic research, I highlight the different ways that clinical scientists interpret epigenetics to target particular domains of the environment for prenatal intervention.

Bacteria associated with truffle-fruiting bodies contribute to truffle aroma.

Truffles, symbiotic fungi renown for the captivating aroma of their fruiting bodies, are colonized by a complex bacterial community of unknown function. We characterized the bacterial community of the white truffle Tuber borchii and tested the involvement of its microbiome in the production of sulphur-containing volatiles. We found that sulphur-containing volatiles such as thiophene derivatives, characteristic of T.

No global consensus: a cross-sectional survey of maternal weight policies.

Background: Growing evidence suggests that maternal prepregnancy weight and gestational weight gain are risk factors for perinatal complications and subsequent maternal and child health. Postpartum weight retention is also associated with adverse birth outcomes and maternal obesity. Clinical guidelines addressing healthy weight before, during, and after pregnancy have been introduced in some countries, but at present a systematic accounting for these policies has not been conducted.

Effects of intratesticular injection of bupivacaine and epidural administration of morphine in dogs undergoing castration.

Objective: To determine the intraoperative and postoperative analgesic efficacy of intratesticular or epidural injection of analgesics for dogs undergoing castration.

Design: Randomized controlled trial.

Animals: 51 healthy male dogs.

Intraspecific genotypic variability determines concentrations of key truffle volatiles.

• Aroma variability in truffles has been attributed to maturation (Tuber borchii), linked to environmental factors (Tuber magnatum), but the involvement of genetic factors has been ignored. We investigated aroma variability in Tuber uncinatum, a species with wide distribution. Our aim was to assess aroma variability at different spatial scales (i.