Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge.

Background: Omalizumab treatment suppresses FcepsilonRI expression faster on blood basophils than skin mast cells.

Objective: We used omalizumab to elucidate the relative contributions of basophil versus mast cell FcepsilonRI activation in a nasal allergen challenge (NAC) model.

Methods: Eighteen subjects with cat allergy were enrolled in a 3.