Publications by authors named "Vakulenko N"

Unlabelled: Posterior capsule striae are the typical consequence of phacoemulsification; the data of their influence on visual acuity is still contradictory.

Purpose: To estimate the influence of posterior capsule striae on visual acuity within one year after implantation of three models of acrylic intraocular lenses (IOLs).

Material And Methods: Seventy-two patients (91 eyes) were followed up for 12 months after implantation of one of models of IOLs: MIOL-2 (24 eyes, first group), SA60AT and US60MP (41 and 26 eyes, second and third groups, respectively).

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Histopathologic changes in the brain and spinal cord in multiple myeloma are similar to those seen in toxic encephalopathy with circulatory disorders. Irreversible morphologic changes in the brain and spinal cord are more pronounced in the encephalopathic syndrome. The structures affected most are the cerebral cortex, brain pedicles, medulla oblongata, spinal cord and its radicles.

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[Selectivity of cerebral neuronal lesions in atherosclerosis].

Zh Nevropatol Psikhiatr Im S S Korsakova

November 1983

Clinical, histological and biochemical studies of the brain in 100 cases of atherosclerosis with relatively similar intensity of changes in the cerebral vascular walls (over 50% of the intima surface being impaired) were carried out. Correlation of the corresponding parameters in groups of diseases differing by their clinical picture permitted the author to ascertain that the selective vulnerability of the cortical neurons in the cerebral hemispheres is dependent on both the intensity of their physiological activity and on the nature of lipid metabolism disorders secondary to dystrophic processes.

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Results of clinico-morphological and biochemical examinations of 66 autopsy cases are presented. At lifetime the deceased were suffering from atherosclerosis: 16 of them showed no psychotic disturbances; 14 had a pseudoparalytic, 20 a lacunar, and 14 a senile-like form of dementia. With the use of histological staining 22 brain specimens were examined.

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The data obtained from studies of 48 postmortem cases of atherosclerotic dementia with the use of histological and biochemical methods demonstrated a prevalence of ischemic changes in the nervous cells, cells-shadows, demyelinization, fragmentation of nervous filaments, hyperplasia, hypertrophy of astrocytes, a swelling of oligodendroglia compared to other changes. A drop in the amount of lecithin in the brain is the highest, while that in kefaline fractions is the lowest. A drop in the amount of sphyngomyelin occupies a middle place.

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The effect of various agar grades on the size and margin character of the inhibition growth zones in assay of antibiotic activity by the agar diffusion method was studied. It was shown that not all the agar grades could be used in antibiotic activity assay. Depending on the agar type the size of the inhibition growth zones produced by the same antibiotic concentration significantly varied.

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A method for quantitative determination of gentamicin and dimethylsulfoxide (DMSO) in "Gentaplast", a film-forming aerozol preparation was developed. Gentamicin was determined microbiologically after extraction. DMSO was determined by titration with the use of the Redox method.

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On the basis of a pathomorphological and biochemical study of 22 cases with focal hemorrhages in atherosclerosis the author detected a contraction of nerve cells, adipose infiltration, "shadow-cells", a deposit of ferrum in the cytoplasma. The swelling of myelinic fibres was detected more often than hypermyelinization, fragmentation and demyelinization. Glia changes consisted in ameboid transformation and clasmatodendrosis.

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Gentamycin prepared at the All-Union Research Institute of Antibiotics did not differ by its antibacterial spectrum and the activity level from gentamycin samples from other countries. By its activity against clinical strains of Ps. aeruginosa gentamycin was somewhat inferior than polymyxin but much more superior than carbenicillin.

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Stability of gentamycin in solutions at various pH levels was studied. It was shown that in acid media inactivation proceeded according to the equation of the 1st order reaction. Dependence of the inactivation rate constant on the temperature corresponded to Arrenium equation.

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A colorimetric method for guantitative determination of neomycin in the aerozol preparation "Neotizol" was developed. The determination was performed after neomycin isolation from the film-forming composition with the carboxylic ion exchange resins IRC-50 and KB-2 containing 2.5-3 per cent of divinylbenzol.

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