Selinexor, a selective inhibitor of nuclear export, inhibits human neutrophil extracellular trap formation .

Neutrophils are central players in the innate immune system. To protect against invading pathogens, neutrophils can externalize chromatin to create neutrophil extracellular traps (NETs). While NETs are critical to host defense, they also have deleterious effects, and dysregulation of NETs formation has been implicated in autoimmune diseases, atherosclerosis and thrombotic conditions, cancer progression and dissemination, and acute respiratory distress syndrome.

[The trends in primary morbidity of adult population of the Russian population during implementation of state programs].

The article presents the results of analysis of indices of primary morbidity of adult population in the Russian Federation during implementation of state programs. The purpose of the study was to study the dynamics of indices of primary morbidity of adult population of Federal districts and subjects of the Russian Federation in 2006-2011 and 2012-2018. The analysis established the subjects of the Russian Federation where the mentioned indices factually remained unchanged or had negative dynamics.

[The quality of coding medical information as component of system of management of medical activities quality].

The reliable statistical information is undoubtedly an important point in making any management decisions. The main instrument for recording and analyzing health data is international statistical classification of diseases and related health problems, 10th revision. The article presents results of study of quality of coding information concerning hospital morbidity and mortality of patients of palliative care department of multidisciplinary hospital.

[Opportunities and Problems of Analysis of Mortality from Myocardial Infarction According to Medical Certificates of Death (on the Example of the Tula Region)].

Aim: to analyze the quality of completion medical certificates of death (MCD) of residents of the Tula region, in which in 2017 acute and subsequent myocardial infarction (MI) was listed as the underlying cause of death (UCD) or as multiple causes of death (MC).

Materials And Methods: From the electronic database (DB) of MCD of residents of Tula region for 2017 we selected all MSD in which MI was written down irrespective of a section of MCD. A total of 689 MSD (43.

[Trends in stroke mortality rates in Russia and the USA over a 15-year period].

Aim: to comparatively analyze standardized mortality ratios (SMR) from stroke in the populations aged over 30 years in the Russian Federation and in the USA over a 15-year period.

Material And Methods: The analysis included nontraumatic subarachnoid hemorrhage (NTSH) (a group of ICD-10 codes I60), nontraumatic intracerebral hemorrhage (NTIH) (I61), cerebral infarction (CI) (I63), and stroke, not specified as hemorrhage or infarction (SNSHI) (I64). The new European standard (European Standard Population.

comprehensive model driven analysis of the electron transfer metabolism and synthetic strain design for biomining applications.

is a gram-negative chemolithoautotrophic γ-proteobacterium. It typically grows at an external pH of 2 using the oxidation of ferrous ions by oxygen, producing ferric ions and water, while fixing carbon dioxide from the environment. is of great interest for biomining and environmental applications, as it can process mineral ores and alleviate the negative environmental consequences derived from the mining processes.

[The order of coding road traffic injuries in accordance with ICD-10 at government forensic medical expertise institutions of the Russian Federation].

The authors describe the order of coding road traffic injuries in accordance with the 10th edition of the International Classification of the Disease (ICD-10) at government forensic medical expertise institutions of the Russian Federation. In addition, they analyse the application of the coding rules and the identification of the primary causes of death with a view to obtaining reliable road traffic accident mortality statistics compatible with the respective internationally available data. Special attention is given to the consideration and recommendation of the rules for making forensic medical diagnosis in accordance with the requirements of ICD-10 and its inclusion in the road traffic death certificates.

[Procedure for coding the causes of death in some circulatory system diseases].

The paper deals with the unification of requirements for coding the causes of death in circulatory system diseases, by taking into account the recently updated ICD-10 and the Consensus of the Expert Council Task Force on Pathological Anatomy, Ministry of Health of the Russian Federation (27 February 2014).

Continuous modeling of metabolic networks with gene regulation in yeast and in vivo determination of rate parameters.

A continuous model of a metabolic network including gene regulation to simulate metabolic fluxes during batch cultivation of yeast Saccharomyces cerevisiae was developed. The metabolic network includes reactions of glycolysis, gluconeogenesis, glycerol and ethanol synthesis and consumption, the tricarboxylic acid cycle, and protein synthesis. Carbon sources considered were glucose and then ethanol synthesized during growth on glucose.

Bone-specific alkaline phosphatase activity is inhibited by bisphosphonates: role of divalent cations.

Bisphosphonates (BPs) are drugs widely used in the treatment of various bone diseases. BPs localize to bone mineral, and their concentration in resorption lacunae could reach almost millimolar levels. Bone alkaline phosphatase (ALP) is a membrane-bound exoenzyme that has been implicated in bone formation and mineralization.

Therapeutic potential of GP IIb/IIIa receptor antagonists in acute myocardial infarction.

The management of acute myocardial infarction (AMI) has changed dramatically over the last two decades, with the addition of fibrinolytic agents and primary coronary intervention (PCI). The more recent development of the glycoprotein (GP) IIb/IIIa antagonists, a new class of potent antiplatelet drugs, has the potential to considerably enhance the treatment of AMI patients. A number of recent studies have highlighted the potential incremental benefits with adjunctive IIb/IIIa-targeted therapy.