Publications by authors named "Vaishnavi Nivsarkar"
Article Synopsis
- In meiosis, the formation of DNA double-strand breaks (DSBs) by the protein Spo11 kickstarts recombination and is essential for proper chromosome segregation.
- Research focuses on Mer2, a key factor in the DSB machinery, showing it interacts with histone reader Spp1 and nucleosomes to help tether DSB factors to chromatin.
- The study identifies a crucial conserved region within Mer2 that interacts with the DSB factor Mre11, positioning Mer2 as a central player in coordinating essential protein complexes necessary for initiating meiotic recombination.
Maintenance and deployment of the immune system are costly and are hence predicted to trade-off with other resource-demanding traits, such as reproduction. We subjected this longstanding idea to test using laboratory experimental evolution approach. In the present study, replicate populations of Drosophila melanogaster were subjected to three selection regimes-I (Infection with Pseudomonas entomophila), S (Sham-infection with MgSO4 ), and U (Unhandled Control).
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