SARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure.

SARS-CoV-2 has been shown to cause wide-ranging ocular abnormalities and vision impairment in COVID-19 patients. However, there is limited understanding of SARS-CoV-2 in ocular transmission, tropism, and associated pathologies. The presence of viral RNA in corneal/conjunctival tissue and tears, along with the evidence of viral entry receptors on the ocular surface, has led to speculation that the eye may serve as a potential route of SARS-CoV-2 transmission.

Mass Spectrometry Defines Lysophospholipids as Ligands for Chicken MHCY Class I Molecules.

Chicken (Gallus gallus) MHCY class I molecules are highly polymorphic yet substantially different from polymorphic MHC class I molecules that bind peptide Ags. The binding grooves in MHCY class I molecules are hydrophobic and too narrow to accommodate peptides. An earlier structural study suggested that ligands for MHCY class I might be lipids, but the contents of the groove were not clearly identified.

MicroPulse Transscleral Laser Therapy Dosimetry Utilizing the Revised P3 Delivery Device: A Randomized Controlled Trial.

Purpose: To compare the long-term effectiveness and safety outcomes of 2 treatment dosages of the MicroPulse Transscleral Laser Therapy (MPTLT) procedure on intraocular pressure (IOP) control in patients with primary open-angle glaucoma.

Design: Single-blinded randomized controlled trial.

Subjects: A total of 19 patients with POAG without prior history of incisional glaucoma surgery.

Uveal and capsular biocompatibility of a new hydrophobic acrylic microincision intraocular lens.

Purpose: To evaluate uveal biocompatibility and capsular bag opacification of a new hydrophobic acrylic microincision intraocular lens (IOL) in comparison with a commercially available 1-piece hydrophobic acrylic IOL.

Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.

Posterior capsule opacification prevention by an intraocular lens incorporating a micropatterned membrane on the posterior surface.

Purpose: To evaluate posterior capsule opacification (PCO) with a new hydrophobic acrylic intraocular lens (IOL) featuring a new micropatterned membrane, in comparison with a commercially available 1-piece hydrophobic acrylic IOL.

Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.

Localized calcification of hydrophilic acrylic intraocular lenses after posterior segment procedures.

Purpose: To describe the clinical and laboratory findings in a series of cases of hydrophilic acrylic intraocular lens (IOL) opacification after posterior segment procedures.

Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, USA.

Surface deposits mimicking calcification on a hydrophobic acrylic intraocular lens.

We describe the case of a female patient who had 3-piece silicone intraocular lenses (IOLs) bilaterally implanted after uneventful surgeries in 2007. Nine years later, the IOLs were explanted and exchanged with 3-piece hydrophobic acrylic IOLs because of cloudiness on their posterior aspect. Two years later, a similar finding was observed on the hydrophobic acrylic IOLs, and it was more intense in the left eye.

Characterization of WY 14,643 and its Complex with Aldose Reductase.

The peroxisome proliferator, WY 14,643 exhibits a pure non-competitive inhibition pattern in the aldehyde reduction and in alcohol oxidation activities of human Aldose reductase (hAR). Fluorescence emission measurements of the equilibrium dissociation constants, K, of oxidized (hAR•NADP) and reduced (hAR•NADPH) holoenzyme complexes display a 2-fold difference between them. K values for the dissociation of WY 14,643 from the oxidized (hAR•NADP•WY 14,643) and reduced (hAR•NADPH•WY 14,643) ternary complexes are comparable to each other.